Structure Elucidation of New Pepsin Inhibitor (S-PI)

Effect of Pepsin Inhibitor (S-PI) on the Growth of Rhodotorula glutinis

Sir: Pepsin inhibitor (S-PI), produced by Streptomyces naniwaensis, was found to be an acylpentapeptide with MW 643.1•`4) It in hibited not only pepsin but also acid proteases that are widely produced by various yeasts and fungi, by the formation of a protease-inhibitor complex. The authors intend to make use of S-PI, and therefore aerobically cultured an acid protease producing organism, Rho d...

Structure Elucidation of a New

In the course of our continuing search for novel antimicrobial agents,1-4) we have isolated a novel diketopiperazine, Sch 725418 (1), from culture Micromonospora sp. In this paper, we describe the isolation and structure elucidation of 1 using high resolution ESI-MS and extensive NMR spectroscopic analysis. Fermentation studies of the SP culture 94-00889 were carried out in shake flasks. Stock ...

PI-083, a new platelet aggregation inhibitor.

Epostatin, new inhibitor of dipeptidyl peptidase II, produced by streptomyces sp. MJ995-OF5 II. Structure elucidation.

During the course of screening fermentation broths for new inhibitors of dipeptidyl peptidase II (EC 3.4.14.2), we discovered epostatin (C23H33N3O5) from Streptomyces sp. MJ995-OF5. The taxonomy of producing strain, fermentation, isolation, physico-chemical properties and biological properties have been described in the preceding paper1). Herein we report on the structure determination of epost...

Pepstatin, a new pepsin inhibitor produced by Actinomycetes.

Sir: A specific inhibitor of an enzyme might be useful for the analysis of certain pathogenic phenomena and also perhaps for the treatment of certain diseases. It was postulated that microorganisms because they produce catobolic enzymes may also produce inhibitors of these enzymes. The authors therefore started to search for enzyme inhibitors in microbial culture filtrates and, as reported in p...